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Current Research Projects
Project Title Gene Methylation and Estradiol Levels in Random FNA Samples as Biomarkers for Breast Cancer Risk
Researcher: Seema Khan, Northwestern University, Chicago, MD at Northwestern University
Study Abstract: Current methods to determine breast cancer risk are insufficiently sensitive to select women most likely to benefit from preventive strategies. Our preliminary data support the hypothesis that quantitative molecular markers (DNA methylation and breast tissue hormone concentrations) may provide an individualized risk profile. We will obtain random fine needle aspiration samples from 300 women of varying menopausal and menstrual status and evaluate cumulative gene methylation and breast estradiol concentrations. Ongoing commercial partnership will ensure development of a simple, inexpensive and noninvasive test. This work sets the stage for validation studies to test whether these early changes predict future breast cancer.
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